Effects of oxycodone hydrochloride on anesthesia recovery quality in surgical revascularization for moyamoya disease

doi:10.12092/j.issn.1009-2501.2019.08.013

Abstract

Abstract:

AIM: To evaluate the effects of oxycodone hydrochloride and sufentanil citrate on anesthesia recovery quality in surgical revascularization for ischemic moyamoya disease. METHODS: According to the random number table, fifty-two patients of ischemic moyamoya disease scheduled for surgical revascularization were divided into two groups: oxycodone hydrochloride group (group oxycodone) and sufentanil citrate group (group sufentanil), with 26 cases in each group. When the temporal muscle was ready to be stuck, oxycodone 0.1 mg/kg was injected in group oxycodone and sufentanil 0.1 μg/kg was injected in group sufentanil. At the end of the surgery, the patient were transferred to the PACU.The extubation time, orientation recovery time, PACU stay time were recorded. Mean arterial pressure (MAP) , heart rate (HR) of all patients were recorded at preoperatively and postoperatively different time points. The VAS scores 10 minutes after orientation recovery ,the Ramsay scores 30 minutes after surgery and the incidence of postoperative complications were recorded. RESULTS:Compared with group sufentanil, the extubation time, orientation recovery time, PACU stay time were shorter in group oxycodone（P<0.05）; the incidence of respiratory depression , nansea and vominiting were lower in group oxycodone（P<0.05）.While there was no statistical difference in VAS scores 10 minutes after orientation recovery , Ramsay scores 30 minutes after surgery, hemodynamic parameters at different time points and the incidence of other postoperative complication between the two groups. CONCLUSION:Compared with sufentanil, the use of oxycodone can achieve effective analgesic effect and decrease the incidence of respiratory depression and nansea and vominting, enhance the post-anesthesia recovery quality in patients under surgical revascularization for ischemic moyamoya disease.

Key words: oxycodone, sufentanil, moyamoya disease, surgical revascularization, anesthesia recovery period

CLC Number:

R614

ZHU Bingqing, HAN Mingming, ZHAI Mingyu, YANG Jia, LI Juan. Effects of oxycodone hydrochloride on anesthesia recovery quality in surgical revascularization for moyamoya disease[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2019, 24(8): 928-932.

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