Advances in study of phase II metabolic enzyme expression and activity under diseases status

doi:10.12092/j.issn.1009-2501.2020.06.012

Abstract

Abstract: Phase II metabolism is generally considered to be a process of detoxification and inactivation. The enzymatic binding reaction plays a very important role in the process of drug metabolism and detoxification. Under disease status, the expression and activity of drug phase II metabolic enzymes will also change. The effects of disease on human drug metabolism enzymes may be isozyme selective. Studying the changes of phase II metabolic enzymes under disease status is helpful for understanding the regulation mechanism of phase II metabolic enzymes, and has an important role in further research to guide clinical rational drug usage and disease prevention and treatment. This article reviewed the distribution and function of phase II metabolic enzymes, and described their changes in expression/activity in liver disease, digestive tract disease, diabetes, cancer, neurodegenerative disease, glynecological disease and cardiovascular disease. The changes and causes of various phase II metabolizing enzymes under different disease and disease progression were also discussed.

Key words: phase II metabolic enzyme, disease, gene expression, enzyme activity

CLC Number:

R969.1

ZHANG Yu, PENG Ying, WANG Guangji, SUN Jianguo. Advances in study of phase II metabolic enzyme expression and activity under diseases status[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2020, 25(6): 686-700.

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