Research progress of transcription factor Bach1 in lung diseases

doi:10.12092/j.issn.1009-2501.2026.09.013

Abstract

Abstract:

BTB and CNC homology 1 (Bach1), a crucial transcriptional repressor within the basic leucine zipper protein family, is ubiquitously expressed across various mammalian tissues. It plays significant roles in key biological processes such as oxidative stress, heme metabolism, ferroptosis, angiogenesis, vascular remodeling, epigenetic modification, glycolysis and mitochondrial function. This article primarily reviews the research progress of Bach1 in lung diseases, aiming to provide new insights for further investigation into its regulatory mechanisms and to explore its potential value as a therapeutic target.

Key words: BTB and CNC homology 1, transcription factors, lung diseases

CLC Number:

R563
R363

Ai MA, Xiaofeng LI, Xiaoju LIU. Research progress of transcription factor Bach1 in lung diseases[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2026, 31(9): 1265-1274.

Figures/Tables 3

References 58

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