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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2017, Vol. 22 ›› Issue (10): 1162-1166.

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A comparison of clinical applications of transdermal estradiol and estradiol valerate on endometrial receptivity in frozen-thawed embryo transfer cycles

JIN Congcong, WANG Peiyu, LIN Jia, ZHOU Wei, YANG Haiyan   

  1. Department of Reproductive Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China
  • Received:2017-04-05 Revised:2017-07-14 Online:2017-10-26 Published:2017-11-13

Abstract:

AIM: To compare the clinical outcome of two endometrial preparation protocols (oral estradiol vs 17β-estradiol transdermal gel) in frozen-thawed blastocyst transfer.  METHODS: One hundred and twenty FET cycles were analyzed from July 2016 to December 2016. All cases were divided into two groups: group A (n=60) received transdermal gel application for 60 cycles, while group B received (n=60) oral estradiol valerate for 60 cycles. Patient's age, basic endocrine, endometrial thickness on the day of progesterone initiation, high quality embryo rate, mean number of embryo transferred per patient, implantation rate, clinical pregnancy rate, early abortion rate and ectopic pregnancy rate were compared between the two groups. RESULTS: Clinical pregnancy rate and implantation rate of group A (63.63% and 52.72%) were higher than those of group B(61.11% and 46.29%, respectively), but there were no statistically significant difference (P>0.05). The total amount of estradiol used[(102.6.8±34.10 vs 85.52±17.18) mg] in group A was significantly higher than that in group B(P<0.05), and the total duration of estradiol used[(16.80±4.02) vs (12.64±2.52) d] in group A was significantly higher than that in group B (P<0.05).No significant differences of other indicators were observed between the two groups. CONCLUSION: In frozen-thawed embryo transfer, estradiol transdermal gel endometrial preparation protocol can obtain the similar pregnancy rate compared with taking estradiol valerate . Estradiol transdermal gel can be used as an effective clinical method for patients with abnormal liver function and hyperlipidaemia. Yet, the dosage and span time increased, estradiol transdermal gel as a regular recommendation still need further discussion.

Key words: estradiol, frozen-thawed embryo transfer, transdermal, endometrial preparation, pregnancy outcome

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