Progress in application of humanized hemato-lymphoid system mice in human acute leukemia model

Abstract

Abstract:

Despite a continuous improvement in xenograft models, engraftment of human malignant cells remains challenging in research of human hematopoiesis.In order to investigate the molecular mechanism involved in human leukemia and to improve therapy, establishing xenograft models that faithfully replicated the disease is critically important. Humanized mice are generated by transplanting human hematopoietic cells into recipient mice. An ideal model would be a humanized mouse in which the human graft fully replaces the endogenous mouse hematopoietic and immune systems. For this purpose, there are three basic requirements: tolerance by the mouse host, correct spatial location and appropriately cross-reactive support and interaction factors such as cytokines and major histocompatibility complex molecules.Here we review the achievements, most recent developments, and the remaining challenges in the generation of pre-clinically-predictive systems for human hematology, which closely resembling the human situation in the xenogeneic mouse environment.

Key words: humanized hemato-lymphoid system mice, xenograft, acute leukemia

CLC Number:

R733.7

CHENG Liyan，TU Linglan，YAN Dongmei，WANG Xiaoju，ZHENG Xiaoliang. Progress in application of humanized hemato-lymphoid system mice in human acute leukemia model[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(10): 1195-1200.

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