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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2018, Vol. 23 ›› Issue (1): 47-50.doi: 10.12092/j.issn.1009-2501.2018.01.009

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Mechanism of ethanolic extract of root of Anacyclus pyrethrum on two models of inflammation

HUANG Hai 1, LIU Changjiang 2, JIN Xiaoyue 2   

  1. 1 Xinjiang Medical University, Urumqi 830054, Xinjiang, China; 2 The Sixth Clinical Hospital of Xinjiang Medical University, Urumqi 830002, Xinjiang, China
  • Received:2017-06-12 Revised:2017-08-29 Online:2018-01-26 Published:2018-02-07

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Abstract:

AIM: To study the effects of ethanolic extract of root of Anacyclus pyrethrum (EERAP) on two models of inflammation.  METHODS: Fifty mice were randomly divided into Control group (received water), EERAP groups of high dose (640 mg/kg), middle dose (320 mg/kg), low dose (160 mg/kg) and Aspirin (120 mg/kg) group. Two models of inflammation were established through mice induced by xylene and RAW264.7 cells induced by lipopolysaccharide (LPS). The anti-inflammatory and antioxidant activity mechanisms were investigated by detecting the contents of malondialdehyde (MDA) in inflammatory tissue, the activity of SOD in serum, while NF-kB and TNF-alfa in RAW264.7 cells. RESULTS: Compared with the control group, different concentrations of EERAP had significant inhibition on the auricle swelling and capillary permeability (P<0.01), and increased the activity of SOD and MDA in serum in mice in vivo (P<0.01), while reduced the contents of TNF-alfa and NF-kB in RAW264.7 cells in vitro. CONCLUSION: The anti-inflammatory and antioxidant activity mechanism of EERAP might be related to the reduction of MDA and NF-kB, and the elevation of SOD and NF-kB.

Key words: Anacyclus pyrethrum, inflammatory model, anti-inflammatory, antioxidant

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