Study on the differences gene between proximal and distal colon cancer based on GEO database by bioinformatics

doi:10.12092/j.issn.1009-2501.2018.04.010

Abstract

Abstract:

AIM: To investigate the distinguish differences gene and its key pathways by analyzing the microarray data of the colon cancer patients with location information. METHODS: Gene expression profiles of the colon cancer with the information of location information in GEO database were selected. Then, using the GO gene functional annotation and KEGG pathway enrichment analysis, screening can represent different characteristics of location of colon cancer gene cluster & pathway, and visualization analysis for protein interaction network. RESULTS: After bioinformatics analysis, it was found that location affected the biological characteristics of colon carcinoma, and significantly altered some important tumor signaling pathways, such as Wnt signaling pathway, extracellular matrix related pathways and immuno-regulatory pathways. CONCLUSION: This study employed bioinformatics method from various perspectives to define the gene expression characteristics of different location in colon carcinoma. These results may provide theoretical basis for accurate treatment of colon cancer.

Key words: distal colon cancer, proximal colon cancer, differential gene expression, bioinformatics

CLC Number:

R735.3

ZHANG Yiwen, LOU Qianwen, ZHONG Like, PAN Zongfu, FANG Luo, HUANG Ping. Study on the differences gene between proximal and distal colon cancer based on GEO database by bioinformatics[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(4): 422-427.

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