Abstract:

 AIM: To investigate the clinical effect of dinoprostone suppositories combined with cefuroxime in the treatment of preterm premature rupture of membranes and effects on  interleukin-6 (IL-6), C reactive protein (CRP). METHODS: One hundred and four cases of premature rupture of membranes were divided into the trial group and the control group, 52 cases in each group. All patients were given intravenous infusion of cefuroxime. The control group received oxytocin to induce labor. The trial group was given dinoprostone suppositories for induction. The birth outcomes of the two groups were recorded, including vaginal delivery/cesarean section, labor time, total stage of labor, postpartum hemorrhage and intrauterine infection. Neonatal conditions were observed, including neonatal weight, Apgar score, fetal distress and neonatal asphyxia. The levels of serum CRP and IL-6 were detected in two groups at admission and after labor. RESULTS: The total effective rate of the trial group was significantly higher than that of the control group, the difference was statistically significant (P <0.05). The cesarean section, labor time, total stage of labor and intrauterine infection in the trial group were significantly lower than those in the control group, the difference was statistically significant (P<0.05). Comparison of postpartum hemorrhage volume between two groups was not statistically significant (P >0.05). Comparison of neonatal weight, Apgar score, fetal distress and neonatal asphyxia between the two groups was not statistically significant (P >0.05). CRP in the two groups increased significantly after parturition, and IL-6 decreased significantly (P <0.05). The levels of CRP and IL-6 in the study group were significantly lower than those in the control group, the difference was statistically significant (P <0.05). CONCLUSION: Dinoprostone suppositories combined with cefuroxime has definite effect on the treatment of preterm premature rupture of membranes, and can increase the rate of vaginal delivery, reduce the rate of intrauterine infection.

Key words: dinoprostone suppositories, cefuroxime, premature rupture of membranes, intrauterine infection, oxytocin