Abstract:

AIM: To evaluate the therapy efficacy and safety of nimodipine combined with flunarizine for preventing and treating migraine. METHODS: Eligible papers about randomized controlled trials of nimodipine combined with flunarizine for preventing and treating migraine and published between 2000 and 2017 were retrieved from PubMed and from online Chinese periodicals, the full-text databases of Wan Fang, VIP and the Chinese National Knowledge Infrastructure.J adad scale was used to assess the quality of included articles and a meta-analysis was performed by RevMan 5.3 software. RESULTS: A total of ten papers were included finally after assessing the quality of studies. A total of 423 people were in the experimental group, in which 398 cases were effective. The control group was 423,in which 324 cases were effective. Meta-analysis showed that there was a significant difference between experimental group and control group［OR=4.87,95%CI（3.07，7.74）, P＜0.01］. Subgroup analysis was performed based on dose and course of treatment. The result showed that it had no heterogeneity between subgroups and different subgroups all had treatment effect. The difference of adverse effect was statistical between two groups［OR=0.41，95%CI（0.20，0.85），P=0.02］. After treatment, symptoms score evaluation of experimental group was better than the control group (P＜0.01). CONCLUSION: The nimodipine combined with flunarizine showed better efficacy and safety for migraine compared with flunarizine alone.

Key words: nimodipine, flunarizine, migraine, Meta-analysis