Abstract:

AIM: To explore the safety and efficacy of Guizhi Fuling capsule in improving the pregnancy outcome of patients with mild endometriosis infertility.  METHODS: Sixty cases of laparoscopy confirmed mild endometriosis admitted to our department of gynecology, according to the random control table, they were divided into the control group and the experimental group. Thirty cases in the control group were given the routine Goserelin Acetate Sustained-Release Depot subcutaneous injection, and thirty cases in the experimental group were treated with Guizhi Fuling capsule orally. After treatment, the clinical efficacy, ovulation rate, pregnancy success rate and abortion rate, ERK-5, p-ERK of two groups were compared. RESULTS: Compared with the control group, the total clinical effective rate was higher in the experimental group (P<0.05), and the ovulation rate (90%, 27/30) in the experimental group was higher than that in the control group (66.67%, 20/30) (χ²=4.81, P<0.05), and the survival rate (76.67%, 23/30) in the experimental group was higher than that in the control group (33.33%, 10/30) (χ²=11.38, P<0.05). In the experimental group, the abortion rate (3.33%, 1/30) was lower than that in the control group (20%, 6/30) (χ²=4.04, P<0.05). After treatment, the ERK-5 levels in the experimental group and the control group were (10.81±3.29), (13.34±2.16) μg/mL, respectively; p-ERK were (0.99±0.17), (1.59±0.27) μg/mL, respectively (all P<0.05). CONCLUSION: Guizhi Fuling capsule can significantly improve the clinical efficacy and pregnancy success rate of patients with mild endometriosis infertility.

Key words: Guizhi Fuling capsule, mild endometriosis, infertility