Abstract:

AIM: To investigate the curative effects of Wuling capsule combined with agomelatin in female patients with depression and sleep disorders and its effect on neurotransmitters and endocrine hormones. METHODS: A total of 128 female patients with depression and sleep disorder who were treated in our hospital from January 2016 to May 2018 were selected and were randomly divided into combined group (64 cases) and single group (64 cases). The single group was treated with agomelatine and the combined group was treated with agomelatine and Wuling capsules. After 8 weeks of continuous treatment, the clinical efficacy, HAMD score, PSQI score, neurotransmitter and endocrine hormone levels were observed in the two groups. RESULTS:After 8 weeks of treatment, the total effective rate was 93.75% in the combined group and 81.25% in the single group, the difference between the two groups was statistically significant (P<0.05). After 4 and 8 weeks of treatment, the HAMD score and PSQI score of the two groups were significantly lower than those before treatment (P<0.05), and the combined group was significantly lower than the single group (P<0.05). After treatment, the levels of 5-HT, NE and E2 were significantly higher than those before treatment (P<0.05), and the combined group was significantly higher than the single group (P<0.05). After treatment, FSH levels in the two groups were significantly lower than those before treatment (P<0.05), and the combined group was significantly lower than the single group (P<0.05). There was no significant difference in adverse reactions between the two groups (P>0.05). CONCLUSION: Wuling capsule combined with agomelatin has a good effect on female depression patients with sleep disorders, it can significantly improve the levels of sleep disorders, neurotransmitters and endocrine hormones, and does not increase adverse reactions, which is of high clinical value.

Key words: Wuling capsule, agomelatin, depression, sleep disorders, neurotransmitters, endocrine hormones