Correlation analysis of common bacterial resistance and antimicrobial use in a tertiary hospital

doi:10.12092/j.issn.1009-2501.2019.07.009

Abstract

Abstract:

AIM: To investigate the correlation between antimicrobial drug use and bacterial drug resistance, and to provide reference basis for clinical rational use of antimicrobial drugs. METHODS: The usage of commonly used antibacterial drugs and the drug resistance rate of bacteria isolated from clinical specimens in the hospital from 2012 to 2017 were investigated and statistically analyzed using SPSS 20.0 software.RESULTS:Among the common gram-negative bacteria in the hospital, the drug resistance rate of escherichia coli was correlated with DDDs of amikacin and imipenem (r=-0.957，P=0.011) and r=0.881 (P=0.048), respectively. The drug resistance rate of klebsiella pneumoniae was correlated with DDDs of imipenem (r=0.949，P=0.014).Among gram-positive bacteria, the drug resistance rate of staphylococcus haemolyticus was correlated with DDDs of levofloxacin, and the correlation coefficient was r=0.975 (P=0.025).CONCLUSION: There is a correlation between the amount of antimicrobial drugs and bacterial drug resistance.

Key words: antimicrobial agents, bacterial resistance, correlation, drug sensitive experiment

CLC Number:

R965.2
R37

SHENG Xuehe，XU Jinying，WANG Youlin，YIN Qin. Correlation analysis of common bacterial resistance and antimicrobial use in a tertiary hospital[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2019, 24(7): 778-785.

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