Therapeutic drug monitoring and pharmacokinetics of new coronavirus pneumonia antiviral drugs

doi:10.12092/j.issn.1009-2501.2020.05.014

Abstract

Abstract: The recent outbreak of pneumonia caused by new coronavirus (SARS-CoV-2) infection has brought major challenges to public health and governance in various countries. At present, there is no clinically specific drug for SARS-CoV-2, and most of the antiviral drugs used are drugs for the treatment of severe acute respiratory syndrome (SARS) and Middle East Respiratory Syndrome (MERS). This article aims to organize and analyze the antiviral drugs and their pharmacokinetic characteristics, and to discuss the characteristics and necessity of therapeutic drug monitoring (TDM), so as to provide a reference for the safety of anti-SARS-CoV-2 treatment.

Key words: new coronavirus pneumonia, antiviral drugs, therapeutic drug monitoring, adverse reactions, pharmacokinetics

CLC Number:

ZHANG Lu, LIN Liangmo, LIU Keke, HUANG Yamin, HUANG Xingxing, YANG Yongyu, XIAO Jian. Therapeutic drug monitoring and pharmacokinetics of new coronavirus pneumonia antiviral drugs[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2020, 25(5): 566-575.

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