Abstract: AIM: To investigate the effect of Guanxinhuoyu Capsule against hypoxia after injection of isoproterenol and in rats with acute myocardial ischemia induced by pituitary.METHODS: The anti-hypoxia model was established by injection of isoproterenol and the acute myocardium ischemia rat model was established by caudal venous injection of pituitrin.The survival time and the changes of the T wave in lead II ECG and heart rate were observed.RESULTS: Guanxinhuoyu Capsule for low and medium dose groups compare with model group, could significantly prolong the survival time by isoproterenol in mice and significantly lower the percentage change of T wave inhibit slowed heart rate induced by pituitrin in rats, and notably decrease the levels of CK, LDH and AST.CONCLUSION: Guanxinhuoyu Capsule reduces myocardial-oxygen consumption and anti-myocardial ischemia effect in rats with acute myocardium ischemia induced by pituitary.

Key words: Guanxinhuoyu Capsule, Pituitary, Myocardial ischemia, Electrocardiogram, Anti-hypoxia  ,  ,  ,  ,