Effects of acute hypervolemic hemodilution with 6%HES 200/0.5 on hemorrheology with diabetes mellitus-2types

Abstract

Abstract: AIM: To investigate the effects of acute hypervolemic (AHH)with 6%Hetastarch 200/0.5 on hemorrheology in patients with diabetes mellitus-2types. METHODS: Twenty ASAⅠ-Ⅱpatients with diabetes mellitus-2types were randomly divided into 2 groups(n=10 each). Group H:received with sodium lactate liquid 500 mL at 15 mL·kg^-1·h^-1, followed with HES 200/0.5 500 mL at the same speed. Group R: performed with sodium lactate liquid 1000 mL at the same speed. After anesthesia induction, blood sample were obstained before and after AHH for measurement of whole blood viscosity at low or high shear rate,plasma viscosity,hematocrit(Hct), RBC aggregation anddeformation index. MAP, HR and SpO₂ were recorded, volume of blood and fluid transfusion were recorded. RESULTS: MAP and HR were stable during AHH period. Compared with group R,WBV at low or high shear rates, RBC aggregation index were significantly decreased, while RBC deformation index were significantly increased after AHH in group H(P＜0.01). CONCLUSION: 6%HES 200/0.5 is better than sodium lactate liquid in improving intraoperative and sluggish blood flow.

Key words: Hetastarch, Hemodilution, Diabetes mellitus, Hemorrheology , , , ,

CLC Number:

R614

ZHOU Chun-lian, ZHOU Gang,CHEN Lin-yang. Effects of acute hypervolemic hemodilution with 6%HES 200/0.5 on hemorrheology with diabetes mellitus-2types[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(1): 88-92.

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