Therapeutic effect of β-elemene on early optic neuritis in experimental allergic encephalomyelitis mice

Abstract

Abstract: AIM: To investigate the therapeutic effect of β-elemene on early optic neuritis in experimental allergic encephalomyelitis (EAE)mice. METHODS: The morphological changes of optic nerve in EAE group and β-elemene treated group were observed by morphology;the expression of β-amyloid precursor protein(β-APP)and 2,3-cyclic nucleopide 3-phosphdiesterase(CNPase) proteins were detected by immunohistochemistry. RESULTS: Compared with the EAE model group,the inflammation of optic nerve in β-elemene treated group was reduced, the expressions of CNPase were increased(31.8±1.0 vs 10.6±0.7, P<0.05)and the expressions of β-APP were decreased(80.4±9.4 vs 182.7±9.1, P<0.05)in β-elemene treated group. CONCLUSION: β-elemene can protect the optic nerve myelin and axon from the damage in EAE mice.

Key words: β-elemene, Experimental allergic encephalomyelitis, β-amyloid precursor protein, 2,3-cyclic nucleopide 3-phosphdiesterase

CLC Number:

R965.2

ZHANG Rong-wei, CHEN Lei. Therapeutic effect of β-elemene on early optic neuritis in experimental allergic encephalomyelitis mice[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(10): 1128-1132.

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