Abstract: AIM: To investigate the influencing factors of cerebral infarction patients with aspirin prevention failure. METHODS: 139 cerebral infarction patients with aspirin prevention failure and 24 community health examination cases who were regularly administered aspirin for long-term, were enrolled in the study. Everybody's medical history was recorded. Medical examinations included the measurement of weight, height, fasting blood lipid, glucose concentrations, and blood routine. The concentration of urinary 11-dehydrothromboxane B₂ of 60 patients without atrial fibrillation and 24 community health examination cases were determined. The clinical influencing factors of patients with aspirin prevention failure were compared with the controls. RESULTS: As compared with the controls, there were statistically significant differences in percentage of male, smoking, previous cerebral infarction, atrial fibrillation, high-density lipoprotein cholesterol concentrations and urinary 11-dehydrothromboxane B₂ concentrations(P<0.05). The results of logistic regression showed that there were significant correlation between aspirin failures and previous cerebral infarction, urine 11-DH-TXB₂ concentrations. CONCLUSION: It is suggested that male, smoking, previous cerebral infarction, atrial fibrillation, low high-density lipoprotein cholesterol are risk factors of aspirin failures. Aspirin resistance is an important risk factor for aspirin failures.

Key words: Cerebral infarction, Aspirin, Aspirin resistance