Abstract: AIM: To investigate the effect of polymorphisms in ApoCⅠ gene on the treatment efficacy of small dose of atorvastatin on hyperlipidemia. METHODS: 94 cases in 387 patients with hyperlipidemia were treated with oral administration of atorvastatin 10 mg/d. The TC,TG, LDL-C,apoA1 and apoB were measured before treatment and after 4,8,12 weeks of treatment. The polymorphisms of ApoCⅠgene on HpaⅠlocus were determined by using PCR- RFLP method. RESULTS: In 387 patients, the relative frequency of H2 allele and H1 allele were 0.3165 and 0.6835,respectively. After 8 weeks of treatment, the decreasing in level of LDL-C was more prominent in non H2 carriers than that in H2 carriers (P<0.05),but this difference was not found in TC, TG and ApoB. CONCLUSION: The efficacy of lipid-lowering therapy was no difference in Apo CⅠ gene polymorphisms.

Key words: ApoCⅠ, Gene polymorphism, Hyperlipidemia, Atorvastatin