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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2010, Vol. 15 ›› Issue (5): 524-529.

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A mutli-center randomized double-blind controlled trial on the functional difference between Fritillaria unibracteata Hsiao et K.C.Hsia and Fritillaria delavayi Ftanch in relieving acute bronchitis (heat phlegm cough)

DING Hong1, YAN Bo-hua1, LIU Song-shan1, YANG Ren-xu1, ZHANG Rui-ming2, ZENG Dai-wen3, CHEN Yun-feng4, LI Ming-quan1, ZENG Jie-ping1, LI Ji-shu5, ZHOU Yi5, HUANG Xiao-yan6   

  1. 1Sichuan Province Hospital of Traditional Chinese Medicine,Chengdu 610075,Sichuan, China;
    2West China Hospital of Sichuan University,Chengdu 610041,Sichuan,China;
    3Sichuan Provincial People's Hospital,Chengdu 610072,Sichuan,China;
    4Chengdu First People's Hospital,Chengdu 610041, Sichuan,China;
    5Chengdu University of Traditional Chinese Medicine Chengdu 610075,Sichuan,China;
    6Chengdu Kanghong Pharmaceutical Co .Ltd. Chengdu 610041, Sichuan, China
  • Received:2010-03-18 Revised:2010-03-26 Online:2010-05-26 Published:2020-09-16

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Abstract: AIM: To study the effect of relieving cough and resolving phlegm between different species of Chuan Fritillaria (Fritillaria unibracteata Hsiao et K.C.Hsia and Fritillaria delavayi Ftanch) and identify the most effective ChuanBeiMu in relieving cough and resolving phlegm. METHODS: A total of 216 patients with acute bronchitis (Cough due to Heat Phlegm) were included and randomized into the Fritillaria unibracteata Hsiao et K.C.Hsia group (Superfine powder of Fritillaria unibracteata Hsiao et K.C.Hsia 2g, po, tid.) and Fritillaria delavayi Ftanch group (Superfine powder of Fritillaria delavayi Ftanch 2g, po, tid.). RESULTS: The clinical trial include 210 patients was completed, 106 in Fritillaria unibracteata Hsiao et K.C.Hsia group and 104 in Fritillaria delavayi Ftanch group. From Day 1 to Day 5, the scores of cough the difficult phlegm and the symptom scores of TCM were reduced. The changing of main symptoms in cough and the difficult phlegm were similar between the two groups (P>0.05), The changing of the secondary symptoms in dry throat, yellow urine and dry movement were significant different between the two groups (P<0.05). The total effective rates of Fritillaria unibracteata Hsiao et K.C.Hsia group in relieving cough was 96.3% and the other group was 92.3%. There was no significant different between the two groups (P>0.05). The incidences of adverse effects were similar between the two groups (P>0.05), and no severe adverse effect was observed. CONCLUSION: Either Fritillaria unibracteata Hsiao et K.C.Hsia or Fritillaria delavayi Ftanch can be separately used to treat “heat phlegm cough”. Both of them can release the symptoms of cough, the difficult phlegm, chest tightness, dry throat, yellow urine and dry movement. There is significant different between the two groups in improving dry throat and dry movement, the Fritillaria unibracteata Hsiao et K.C.Hsia may has a better effect than the Fritillaria delavayi Ftanch.

Key words: Species, Fritillaria unibracteata Hsiao et K.C.Hsia, Fritillaria delavayi Ftanch, Relieving cough, Resolving phlegm

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