Roles of drug metabolism enzymes in drug resistance of tumor

Abstract

Abstract: Tumor chemotherapy is one of the most commonly used and effective treatment in antitumor therapy, but drug resistance usually leads to tumor chemotherapy failure. Drug resistance of tumor is often caused by varied mechanisms, of which the drug metabolism enzymes play very important role. In recent years, researchers found that there were many kinds of drug metabolism enzymes related to drug resistance of tumor. Such as Phase I enzymes (cytochrome P450 enzymes, COX-2), PhaseⅡ enzymes(GST, UGT, GCS, NQO1), and Phase Ⅲ enzymes drug transporter protein. In this article, we reviewed the correlation between drug metabolism enzymes and drug resistance of tumor, in order to provide a new way for anti-tumor therapy.

Key words: Drug metabolism enzyme, Drug resistance, Tumor

CLC Number:

R969

ZHOU Ying, ZHOU Fang, WU Xiao-lan, WANG Guang-ji. Roles of drug metabolism enzymes in drug resistance of tumor[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(12): 1418-1427.

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