Effects of estrogen on estrogen receptors in myocardium of ovariecto-mized female rats

Abstract

Abstract: AIM: To investigate the expression of estrogen receptors in myocardium of ovariectomized fe-male rats.METHODS: One week after bilateral ovariectomy, the female SD rats were divided into 3 groups randomly :OVX +estrogen (0.15 mg/kg,s.c.) , OVX +normal sodium and control .After 4 weeks of treatment, the expression of estrogen receptors in the myocardium were evaluated by Western blotting.RESULTS: After ovariectomy, serum estrogen de-creased significantly, compared with control[( 88±22 vs 403±59) pmol/L, P <0 .05], the expression of estrogen receptors decreased( P<0.05) .After estrogen replacement therapy, serum estrogen increased [( 3864±105) pmol/L], estrogen upregulated the ex-pression of ERβreceptor( P<0.05) and downregulat-ed ERαreceptor (P<0.05) in myocardium .CONCLUSION: Estrogen replacement modifies the expres-sion of estrogen receptors in myocardium of ovariecto-mized female rats.

Key words: estrogen receptor, myocardium, ovariectomy

CLC Number:

R965.2

ZHONG Xiao-hua, WANG Hui, LI Qing-ping. Effects of estrogen on estrogen receptors in myocardium of ovariecto-mized female rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(4): 431-434.

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