Abstract: AIM: To evahuate the efficacy and safety of gabapentin in the treatment of migraine.METHODS: A randomized, double-blind, placebo-controlled study was taken.104 patients( aged 18 to 60 year) with migraine were randomly assigned to receive placebo( control group, 49 patients) or gabapentin( experimental group, 55 patients) for 4 weeks. The efficacy, side effects, TCD and EEG were assessed at the beginning of trials, and 4th， 8th weeks. RESULTS: Comparing with the placebo goup, the frequency，duration and intensity of migraine were markedly decreased in gabapentin group, there was significant difference between groups( P<0.01). The side effects did not differ between groups( P>0.05). CONCLUSION: Gabapentin is an effective and safe agent from migraine.

Key words: gabapentin, migraine, random ized, double-blind