Experimental studies on hypoglycemic activity of active hepatin

Abstract

Abstract: AIM:To observe the hypoglycemic activity of active hepatin in diabetic mouse or rat models. METHODS:The diabetic mice induced by alloxan were i.g.given active hepatin 1.0, 2.0, 4.0g/kg for 8 weeks.The body weight and fasting blood glucose were determined every 2 weeks.The type 2 diabetic SD rats induced by fed with high caloric diet and injected minidose streptozocin, were given active hepatin 0.75, 1.50, 3.00g/kg i.g.for 8 weeks, also the body weight and fasting blood glucose were determined every 2 weeks.In addition, the effect of active hepatin on glucose tolerance was investigated in alloxan-induced diabetic mice.RESULTS:Active hepatin reduced the levels of blood glucose and improved the glucose tolerance, and also decreased the blood sugar curve areas about alloxan-induced diabetic mice which were given the dosages 1.0, 2.0, 4.0g/kg of active hepatin.The blood glucose of type 2 diabetic SD rats induced by fed with high caloric diet and injected with minidose streptozocin could be decreased by 3.00g/kg of active hepatin.CONCLUSION:Active hepatin can adjust bloodsugar level and improve glucose tolerance.

Key words: active hepatin, blood glucose, hypoglycemic effect

CLC Number:

R965.1

ZHANG Xin-yue, LI Qin, CHEN Ai-jun, NI Ya. Experimental studies on hypoglycemic activity of active hepatin[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(8): 847-851.

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