Abstract: The animal models play irreplaceable and vital role in studying the etiology of cholecystitis, exploring its pathogeny and evaluating its treatment measures.The etiopathogenisis of cholecystitis is associated with many factors such as infection, hormone, nerve, metabolism etc.Following simulation clinical bacterium infection models, the application of common duct ligation, vagus nerve excision, food feeding, foreign matter implantation, drug inducing, and stenosis stone formation help to establish a lot of animal models which can simulate the corresponding cholecystitis.All of these models are helpful to evaluate the preclinical pharmacodynamics and further study on the mechanism and treatment measures of cholecystitis.

Key words: cholecystitis, etiology, animal model