Significance of GABAA receptors in the development of some neuropsychiatric diseases

Abstract

Abstract: γ-aminobutyric acid (GABA) is an inhibitory neurotransmitter in the central nervous system (CNS), with wide physiological role via GABA_A, GABA_B and GABA_C receptors. GABA_A receptor, a dominant type of GABA receptors is comprised of different subunits coming from eight subunit clusters. Whereas its typical molecular structure is a hetero-pentameric complex, being comprised of two α, two β and one γ subunits. And different subunits especially different αsubunit combinations give rise to various physiological and pharmacological effects, which makes GABA_A receptor play a great role in the development of some neuropsychiatric diseases such as anxiety, depression, epilepsy and memory disorders etc. Thus GABAA receptor might be an effective target for preventing these neuropsychiatric diseases.

Key words: GABA_A receptor, pharmacological effects, neuropsychiatric disease

CLC Number:

R962

LAI Yan-ping, LIU Yan-qiang. Significance of GABA_A receptors in the development of some neuropsychiatric diseases[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(2): 208-212.

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Significance of GABA_A receptors in the development of some neuropsychiatric diseases

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