Advances on mechanisms of selective estrogen receptor modulators and their therapy of postmenopausal osteoporosis

Abstract

Abstract: The reduction of estrogen is the main cause that leads to osteoporosis(OP). Selective estrogen receptor modulators (SERMs) have been developed and applied for the treatment of postmenopausal OP because breast cancer is triggered while using estrogen to cure OP. SERMs selectively act on the estrogen receptor that could inhibit the absorbability of bone and the formation of osteoclast, this manner may prevent the loss of bone mineral density. Presently, it is considered that SERMs were the ideal drugs for curing postmenopausal OP. In the paper, the functional mechanism of SERMs and their effects on curing OP were summarized, the scientific significance and perspective for application of SERMs on the therapy of postmenopausal OP were discussed.

Key words: selective estrogen receptor modulator, osteoporosis, estrogen receptor

CLC Number:

R965.2
R681

LI Meng-Sen, ZHOU Sheng, LI Gang. Advances on mechanisms of selective estrogen receptor modulators and their therapy of postmenopausal osteoporosis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(2): 213-219.

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