Abstract: AIM: To investigate the effects of edaravone on interleukin(IL)-6,-8 and expression of their mRNA in patients undergoing one lung ventilation(OLV) METHODS: Twenty-four ASA Ⅰ or Ⅱ patients with lung cancer of both sexes aged 48-67 yr undergoing elective lung resection were randomly divided into two groups (n=12 each): Control group (C) and Edaravone group (E). Anesthesia was induced with midazolam 0.03 mg/kg, Fentanyl 3 μg/kg and 8% Sevoflurane, and maintained with intermittent i.v. boluses of vecuronium 0.04-0.08 mg/kg, Fentanyl 0.05-0.1 mg and 1.8%-2.7% Sevoflurane in two groups. Group E was received edaravone 0.5 mg/kg after induction of anesthesia. Blood sample were taken before skin incision (T₁), 60 min after lungs were inflated(T₂)and 1 h after surgery(T₃) for determination of plasma IL-6, IL-8 concentration and expression of their mRNA. RESULTS: The levels of IL-6, IL-8 and their mRNA were all significantly increased at T_2-3 in both group than at T₁(P＜0.05); but the levels of IL-6, IL-8 and their mRNA were lower at T_2-3 in group E than those in group C(P＜0.05). CONCLUSION: Edaravone is effective in reducing inflammatory response in patients undergoing OLV.

Key words: Edaravone, One lung ventilation, Interleukin-6, Interleukin-8, mRNA