Abstract: AIM: To study the bioavailability and bioequvilence of bezafibrate capsule and tablet in health human. METHODS: 20 health volunteers were given bezafibrate capsules and tablets 400mg once with the interval of one week.Plasma samples were obtained and determined with HPLC method.Pharmacokinetics parameters were calculated and compared with DAS software. RESULTS: The main pharmacokinetics parameters of bezafibrate capsules and tablets were as follow:t1 2 (1.9 ±0.5) 、(2.0 ±0.6) h;Cmax (12±4) 、 (11±3) μg mL;tmax (1.7±0.9) 、(1.9±0.7) h; AUC(0-12) (36±10)、(33±7)μg·mL-1·h;AUC(0-∞) (37±10) 、(34±7) μg·mL-1 h.The biovailability of bezafibrate capsule campared to tablet was 92.3%and 92.9%. CONCLUSION: The test bezafibrate capsule is bioequivalent to the reference talbet in health human.

Key words: bezafibrate, bioavailability, HPLC, pharmacokinetics