Abstract: AIM: To provide a rationale of adverse effects in therapy of fosfomycin sodium for injection by characterizing the adverse drug reactions (ADRs) of fosfomycin sodium. METHODS: 148 ADRs repots were pooled and statistically analyzed from domestic literatures from 1997 to 2006 with regard of patients' gender, age, ADRs history, route of medication, clinical manifestation and treatment actions. RESULTS: The patients who had ARDs histories occupied by 75.44% except the patients whose ADRs histories were unknown.The patients experienced ADRs of 86.21% when they simultaneously administered fosfomycin sodium, of which 99.32% of those ADRs were recovered or improved after other medical interventions.One death report was submitted.Most of ADRs were categorized as allergic reaction. CONCLUSION: The clinic apperance of fosfomycin sodium injection was diversified.The main one was allergic reactions.

Key words: fosfomycin sodium, adverse drug reaction, rational administration