Effect of human tissue kallikrein on peripheral nerve injury

Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2009, Vol. 14 ›› Issue (12): 1351-1355.

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Effect of human tissue kallikrein on peripheral nerve injury

LIU Jun¹, WANG Jun-lu¹, HU Xiang-peng², LI Cai-xia³, PENG Ling-li¹

¹Department of Anesthesiology, First Hospital, WenzhouMedical College, Wenzhou 325000, Zhejiang, China;
²Department of Gastroenterology, First Hospital, WenzhouMedical College, Wenzhou 325000, Zhejiang, China;
³Department of Anesthesiology, First Hospital, Zhejiang University, Hangzhou 310003, Zhejiang, China

Received:2009-10-12 Revised:2009-11-06 Published:2020-10-20

Abstract

Abstract: AIM: To verify the therapeutic effection of human tissue kallikrein( HTK) on peripheral nervous system regeneration.METHODS: 30 adult male SD rats weighted 180 -200 g were randomly divided into 3 groups:Sham group, HTK group( 17.5 ×10^-3PNAU kg), Control group( n =10).Calculating sciatic functional index (SFI) and static sciatic index ( SSI) were performed on the day before nerve crushed and day 1, 3, 5, 7, 9, 11, 13 after operation in all rats.The electrophysiological results of the sciatic nerve was determined on the 14th day postoperation.RESULTS: There was no apparent functional deficit in the Sham group before and after operation.The HTK group showed a statistically significant improvement over the control group on the 5th day postoperation.The NCV of the HTK group was greater than the Control group ( P <0.05).CONCLUSION: The treatment of HTK is effective on peripheral nervous system regeneration.

Key words: human tissue kallikrein, peripheral nervous system injury, sciatic functional index, static sciatic index, nerve conduction velocity

CLC Number:

R965.2

LIU Jun, WANG Jun-lu, HU Xiang-peng, LI Cai-xia, PENG Ling-li. Effect of human tissue kallikrein on peripheral nerve injury[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(12): 1351-1355.

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Effect of human tissue kallikrein on peripheral nerve injury

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