Abstract: AIM: To evaluate the efficacy and safety of silybin-phosphatidylcholine compound ( SPC) for patients with chronic hepatitis B( CHB).METHODS: Eighty patients with chronic hepatitis B ( abnormal ALT level)were randomly divided into two different groups:the patients of trial group( n =40) were treated with SPC ( 120 mg, tid) for 12 weeks, and the control group ( n =40) were treated with Chinese herbs compound Huganning pills ( 4 #, tid) 12 weeks.Before and after treatment, the clinical symptom and the serum parameters of liver function and fibrosis were evaluated for the patients of both groups, and the adverse effects were recorded.RESULTS: After treatment, the clinical symptoms were improved in different degree in the patients of both groups, the improvement rate of the fatigue and belly inflation in trial group were obvious higher than those in control group( P <0.05).After treatment, both liver function and fibrosis parameters were significantly improved, and there was no significant difference between the two groups.The gross efficacies in trial group and control group were 75 %, 70 %, respectively.No serious adverse events were reported in both groups.CONCLUSION: It has been suggested that SPC has significant therapeutic effects on chronic hepatitis B, and it is safety.

Key words: silybin, chronic hepatitis B, Chinese herbs compound