Anti-oxidative effect of Jiangtang compound recipe on subacute agingmodel mice

Abstract

Abstract: AIM: To study the effect of antioxidation in subacute aging model mice with Jiangtang compound recipe which composed of kudzuvine root, heartleaf houttuynia herb and Evonymus alatas. METHODS: By using the D-galactose-induced aging mice, the body weight, the content of malondialdehyde (MDA), the activities of superoxide dismutarse(SOD) and glutothine peroxidase (GSH-Px) in serum and tissues were determined. RESULTS: To the model mice, Jiangtang compound recipe (14, 7 g kg, i.g.) reduced the content of MDA, enhanced the activities of SOD and GSH-Px in serum and tissuses, inhibited the decrease of body weight. CONCLUSION: Jiangtang compound recipe shows a remarkable anti-oxidative effect on the D-galactose-induced aging mice.

Key words: Jiangtang compound recipe, D-galactose, malondialdehyde, superoxide dismutarse, glutathione peroxidase

CLC Number:

R965.2

ZHANG Juan, WU Guan-zhong. Anti-oxidative effect of Jiangtang compound recipe on subacute agingmodel mice[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(3): 283-286.

References

[1] 王利勤, 赵友兴, 周露, 等.鱼腥草的化学成分研究[J].中草药, 2007, 38(12):1788-1789.
[2] 王方, 陆付耳, 徐丽君.鱼腥草对糖尿病大鼠肾脏组织中BMP-7 和TGF-β1 表达的影响[J].天津中医药,2006, 23(4):334-337.
[3] 张世平, 方文娟, 吕俊华, 等.葛根素抑制D-半乳糖致大鼠蛋白糖基化的实验研究[J].中药材, 2006, 29(3):266-268.
[4] 黄德彬, 余昭芬.鬼箭羽主要提取物的抗氧化作用[J].中国公共卫生, 2006, 22(6):720-721.
[5] 尚文斌, 程海波, 唐含艳.鬼箭羽对糖尿病小鼠及全血粘度的影响[J].南京中医院大学学报:自然科学版, 2000, 16(3):166-167.
[6] Ha H, Hwang IA, Park JH, et al.Role of reactive oxygen species in the pathogenesis of diabetic nephropathy[J]. Diabetes Res Clin Pract, 2008, 82(1):42-45.
[7] 黄维佳, 巫冠中.降糖复方含药血清对氧化损伤内皮细胞的保护作用[J].中国临床药理学与治疗学,2007, 12(5):562-565.
[8] Zhang Q, Li X, Cui X, et al.D-Galactose injured neurogenesis in the hippocampus of adult mice[J].Neurol Res, 2005, 27(5):552-556.
[9] 曲娴, 方文娟, 李冰, 等.维生素E 对D-半乳糖诱致衰老小鼠脑抗氧化能力、钙稳态和线粒体DNA(mtDNA)损伤的影响[J].中国病理生理杂志, 2008, 24(3):523-526.
[10] 陈奇. 中药药理研究方法学[M].人民卫生出版社,1994:895-939.
[11] 余资江, 应大君, 董世武, 等.半乳糖急性致衰老动物模型剂量的探讨[J].解剖学杂志, 2005, 28(4):422-424.
[12] 杨浩杰, 王治伦, 薛森海.衰老的机制研究进展[J].中国地方病防治杂志, 2008, 23(1):35-37.
[13] Frisard M, Ravussin E.Energy metabolism and oxidative stress:impact on the metabolic syndrome and the aging process[J].Endocrine, 2006, 29(1):27-32.
[14] StojiljkovicV, TodorovicA, Kasapovic J.Antioxidant enzyme activity in rat hippocampus after chronic and acute stress exposure[J].Ann N Y Acad Sci, 2005, 1048(7): 373-376.
[15] Witztum JL.The oxidation hypothesis of atherosclerosis[J].Lancet, 1994, 344:793-795.