Evaluation of anti-inflammatory effects of luteolin and underlying mechanisems

Abstract

Abstract: AIM: To investigate anti-inflammatory effects of luteolin and underlying mechanisems.METHODS: Three typical inflammatory models, carrageenaninduced paw edema, cotton pellet granuloma and air cyst were used to investigate anti-inflammatory effect of luteolin in vivo.Meanwhile, effects of luteolin on mitogen-induced splenocyte proliferation and cyclooxygenase (COX) activities in vitro were also studied.RESULTS: Luteolin reduced the carrageenan-induced paw edema and effectively inhibited the inflammatory process in the cotton pellet granuloma model.Luteolin significantly inhibited leukocytes influx and reduced elevated levels of PGE2 and 6-keto-PGF1αin the exude induced by carrageenan injection.ConA stimulated splenocyte to proliferate, and the response was effectively suppressed by luteolin.In the whole blood assay, luteolin demonstrated selective inhibition of COX-2 activity.CONCLUSION: Luteolin effectively suppresses inflammatory responses in vivo, and the anti-inflammatory activity is associated with its selective inhibition of COX-2.

Key words: luteolin, inflammation, cyclooxygenase

CLC Number:

R965.2

TANG Ning, LI Zi-yan, ZHOU Yong-mei, LIU Bao-lin. Evaluation of anti-inflammatory effects of luteolin and underlying mechanisems[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(2): 195-199.

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