Dose-effect relationship of intrathecal ropivacaine for labor analgesia

Abstract

Abstract: AIM: To determine the dose-effect relationship of intrathecal ropivacaine for labor analgesia. METHODS: One hundred premolars in active labor were included in this randomized trial.Ropivacaine was intrathecally administered in a dose of 1.0, 1.5, 2.2 or 3.3 mg.Premolars were considered responders to spinal analgesia if the visual analog scale score for pain was less than 3 cm within 10 min.Group-specific dose-response curves were constructed using a probit regression model.RESULTS: The ED50 and ED95 of ropivacaine were 1.50 mg (95 % confidence interval: 1.31-1.70mg) and 2.93mg(95 % confidence interval: 2.42-4.16 mg ), respectively.The relationship between the probit of effective analgesic ratio of premolars and the log of dosage of intrathecal ropivacaine was established.Regression equation was Probit (Z)=-1.00478+5.67816(log of dosage).CONCLUSION: The ED50 and ED95 of ropivacaine are 1.50 mg and 2.93 mg, respectively.

Key words: ropivacaine, subarachnoid space, labor analgesia, dosage, effect

CLC Number:

R614

CAI Xiao-lei, VZHONG Hui-zhen, GAN Guo, YUAN Li-yong, HUANG Jian-ping, FANG Chun-feng. Dose-effect relationship of intrathecal ropivacaine for labor analgesia[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(1): 90-93.

References

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