Progress and research in the effect of itraconazole on pharmacokinetic drug-drug interactions

Abstract

Abstract: Itraconazole, as one of the broad-spectrum antifungal drugs, is an inhibitor of CYP3A4 and P-glycoprotein and was widely used in clinic.CYP3A4 and P-glycoprotein with extensive substrate have present at high levels in gastrointestinal tract, the primary site of absorption for orally administrated drugs, and share a significant overlap in substrate specificity, thus resulting in widely pharmacokinetic interaction by itraconazole, part of which has clinical importance.In this article, the effect of itraconazole on pharmacokinetic drug-drug interactions is reviewed and discussed in order to promote its safe usage.

Key words: itraconazole, antifugal drug, pharmacokinetics, drug-drug interaction

CLC Number:

R969

MIAO Cai-yun, CHEN Yi, CHEN Jiang-fei. Progress and research in the effect of itraconazole on pharmacokinetic drug-drug interactions[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(10): 1183-1192.

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