Research development and clinical significance of genetic polymorphism of CYP450

Abstract

Abstract: Cytochrome P450 is the very most important enzyme of drug metabolism.It involves in biotransformation of various endogenous and exogenous compounds, especially for clinical drugs.There are many polymorphisms of gene and phenotype, resulting in significant individual variability of different kinds of compounds.This article reviews the genetic polymorphisms of CYP, the characters and clinical meanings of diverse subgroups that relevant to drug metabolism in recent years.The major object of this article is reasonably explaining and predicting the interaction of clinical drugs and the drug adverse reaction in order to providing scientific evidences for the individual administration in clinic.

Key words: cytochrome P450, genetic polymorphism, drug metabolism

CLC Number:

R969

LI Na, SHI Xiao-jin. Research development and clinical significance of genetic polymorphism of CYP450[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(10): 1193-1200.

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