Application of gene diagnosis in treatment of phenytoin for epilepsy

Abstract

Abstract: To analyze in vivo the metabolic process of phenytoin and the basic theories of gene diagnosis, and introduce the examples of successful application of gene diagnosis in clinical phenytoin usage , and thoroughly expound the theoretical basis , clinical relevance, specific methods , and fields of application of using gene diagnosis to improve the usage of phenytoin ,using recently published literature as a basis.The genetic polymorphism is an important factor that affects the pharmacodynamics , pharmacokinetics , and drug adverse reaction of phenytoin.Gene diagnosis may become an effective way of improving usage of phenytoin and should be used widely in treating epilepsy with phenytoin.

Key words: phenytoin, genetic polymorphism, gene diagnosis

CLC Number:

R971+.6

LIU Yang, SONG Ya-juan, DING Guo-hua. Application of gene diagnosis in treatment of phenytoin for epilepsy[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(4): 465-470.

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