Research progress on the treatment of compensatory Congestive Heart Failure with recombinant human brain natriuretic peptide

Abstract

Abstract: Recombinant human brain natriuretic peptide(rhBNP) is a synthetic peptide, its role is similar to endogenous brain natriuretic peptide, with effects on expanding blood vessel, diuretic, natriuretic, antisympathetic nervous system, decreasing plasma aldosterone and endothelin, also with characteristic of depress urization while neither speeding up the heart rate, nor activating the renin-angiotensin-aldosterone system.A number of studies had confirmed that recombinant human brain natriuretic peptide was effective in the treatment of Congestive Heart Failure(CHF) , it could effectively improve the cardiac function, reduce the cardiac load and reverse left ventricular remodeling.It is now put on to market and applied in clinical treatment of Congestive Heart Failure.The article introduces rh-BNP pharmacologic action, the relationship with CHF, and the research progress on the treatment of CHF.

Key words: brain natriuretic peptide, Congestive Heart Failure, drug therapy

CLC Number:

R541.6+1

ZHONG Mai-ye, JI Qiu-he. Research progress on the treatment of compensatory Congestive Heart Failure with recombinant human brain natriuretic peptide[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(4): 471-474.

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