Abstract: AIM: To study the influence factors on the stability of cefuroxime sodium, ceftriaxone sodium and cefotaxime sodiumin mingled in 0.9% sodium chloride injection and 5% glucose infusion.METHODS: In the condition of different temperatures (8, 25 and 37 ℃), different intensities of illumination (illumination intensity 2500 lx, away from light)and different times (0, 0.5, 1, 2 and 3 h), the contents, pH and insoluble particles of three kinds of injections were detected.RESULTS: In different temperatures and illumination intensity conditions, the contents of three drugs mingled with the two infusions were in a stable state in 3h.With the extension of storage time, the related substances of cefuroxime sodium and ceftriaxone sodium were increased significantly in the transfusions. Yet the cefotaxime sodium was not increased relatively. CONCLUSION: The three drugs mingled with the two transfusions should be used in 3 h, but it is better to use immediately, and cefuroxime sodium and ceftriaxone sodium should be kept away from light.It is useful for increasing the therapeutic effect and promoting the rational use of drugs to know the influence factors on the stability.

Key words: cefuroxime sodium, ceftriaxone sodium, cefotaxime sodium, transfusion, stability, rational administration