Effect of Danhong Zhiganching capsules in rats with experimental fatty liver

Abstract

Abstract: AIM: To study the effect of Danhong Zhiganching capsules on the experimental fatty liver in rats.METHODS: Male SD rats were treated by high fat diet for 6-week after being treated by a low dose of CCl4 to induce fatty liver model.Then, drugs were given by oral to the rats, the contents of triglyeride, total cholesterol in serum and liver tissue, the contents of superoxide dismutase and malondialdehyde in serum and the contents of free fatty acids in liver tissue acted as indexes to determine the effect of Danhong Zhiganching capsules.RESULTS: The contents of triglyeride and total cholesterol in serum and liver tissue of rats were significantly reduced by Danhong Zhiganching capsules, and so it is with the contents of free fatty acids in liver tissue (P<0.01,P<0.05).The contents of superoxide dismutase in serum was increased markedly by Danhong Zhiganching capsules and the contents of malondialdehyde was decreased (P<0.01,P<0.05).CONCLUSION: Danhong Zhiganching capsules show great effects on the experimental fatty liver induced by a low dose of CCl4 and high fat diet.

Key words: non-alcoholic fatty liver, high fat diet, Danhong Zhiganching capsule

CLC Number:

R965.1

LIU Yuan, CHEN Zhen, QIAN Zhi-yu. Effect of Danhong Zhiganching capsules in rats with experimental fatty liver[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2006, 11(7): 818-821.

References

1 Elizabeth M, Brunt MD.Nonalcoholic Steatohepatitis[J].Semin Liver Dis, 200;24:3-20
2 Falck-Ytter Y, Younossi ZM, Marchesini G, McCullough AJ.Clinical features and natural history of nonalcoholic steatosis syndromes[J].Semin Liver Dis, 2001;21:17-26
3 Farrell GC, Larter CZ.Nonalcoholic fatty liver disease:From· 820 · Chin J Clin Pharmacol Ther 200Jul;11(7)steatosis to cirrhosis[J].Hepatology, 200;43:99-112
4 Comar KM, Sterling RK.Review Article:Drug therapy for nonalcoholic fatty liver disease [J].Aliment Pharmacol Ther, 200;23:207-15
5 蒋莉, 戚晓红, 吴翠贞, 李跃华, 李晓宇, 李菁.壳聚糖加首乌、丹参和牛膝对实验性脂肪肝大鼠的保护作用[J].中国新药与临床杂志, 2002;21:462-6
6 张昭萍, 戚晓红, 王瑞云, 吴翠贞.壳聚糖合并中药对脂肪肝治疗作用的实验研究[J].南京中医药大学学报(自然科学版) , 200;17:107-9
7 钟岚, 范建高, 王国良, 吴伟清, 史祺.肥胖、高脂血症性脂肪性肝炎模型的建立[J].实验动物科学与管理, 2000;1:16-20
8 徐厚明, 陈真, 钱之玉.消脂益肝饮降血脂作用的实验研究[J].中国新药杂志, 2003;1:438-40
9 杨晋原.脂肪肝中医辨治五法[J].山西中医学院学报,200;7:44-5
10 彭招华, 袁侣明, 韩民利.丹参的药理作用研究概况[J].中药材, 200;24:690-3
11 陈向荣, 陆京伯, 石汉平.丹参的药理作用研究新进展[J].中国医院药学杂志, 2001;21:44-5
12 高莹, 肖颖.山楂及山楂黄酮提取物调节大鼠血脂的效果研究[J].中国食品卫生杂志, 200;14:14
13 林秋实, 陈吉棣.山楂及山楂黄酮预防大鼠脂质代谢紊乱的分子机制研究[J].营养学报, 2000;22:131
14 李贵海, 孙敬勇, 张希林, 杨振宁, 周超, 杨书斌.山楂降血脂有效成份的实验研究[J].中草药, 200;33:50
15 闫君宝, 金龙, 汪江碧, 丁永辉, 郑天珍, 瞿颂义, 等.山楂对高脂饮食大鼠糖代谢及抗氧化作用的影响[J].四川中医, 200;23:19
16 范建高, 钟岚, 王国良, 徐正婕, 巫协宁.肥胖、高脂血症致脂肪性肝炎发病机制的探讨[J].肝脏, 199;4:171
17 张卓, 李道本.脂肪肝与脂质过氧化[J].中国中西医结合消化杂志, 200;11:251-2

[1]	ZHANG Liang, LIAO Yongqun, XIA Qinchuan, ZHOU Shitong, LI Xiaoli. Ferroptosis regulatory signaling pathway and its research progress in related diseases [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(2): 227-234.
[2]	WU Jiayuan, ZHENG Li, MO Juanfen, GUO Li, CAO Chenxi, BAO Yi. Regulation of N-acetylcysteine on peripheral circulatory and hepatic myeloid-derived suppressor cells in non-alcoholic fatty liver disease mice [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2019, 24(9): 989-996.
[3]	ZHOU Hongping, YANG Xingxin, ZHUANG Rangxiao, SHAO Yidan, XI Jianjun, LIAO Li, REN Bailu, WANG Pingping, YU Shuying, SHI Tingting. Effects of activated carbon N-acetylcysteine sustained-release microcapsule on miRNA of non-alcoholic fatty liver disease in young rats [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(3): 263-270.