Abstract: AIM: To study the effect of total ginkgolides on platelet aggregation and experimental thrombosis.METHODS: The model of artery-vein bypass thrombosis and Chandler' s method were established to observe the effect of total ginkgolides.Platelet activating factor,arachidonic acid and adenosine diphosphate were used to induce platelet aggregation in rabbits and the ratio of platelet aggregation was detected.RESULTS: It was found that total ginkgolides inhibited the artery-vein bypass and Chandler' s s thrombus in different degrees, reduced the thrombus weight significantly (either wet or dry,P<0.01);Total ginkgolides inhibited platelet aggregation with different revulsant at different time, and reduced the maximum aggregation rate.CONCLUSION: Total ginkgolides exerted remarkable effect against thrombosis and possessed strong effect against platelet aggregation induced by ADP and PAF.

Key words: total ginkgolides, thrombosis, platelet aggregation