Abstract: AIM: To investigate the effects of selenocarrageenan syrupus on nonspecific immunity, humoral immunity, cell immmunity of immune suppressed mice with cyclophosphamide. METHODS: Intraperitoneal injecting cyclophosphamide(80 mg/kg, i. d.) in mice for 3 days to make immunity hypofunction mice model and given selenocarrageenan syrupus by gastric gavage for 30 days. We tested the mononuclear phagocyte englobement function, serum haemolysin, delayed hypersensitivity (DTH),interlukine-1, 2(IL-1, 2) activity and T, B lymphocyte proliferating function. RESULTS: High and medium dose(30, 10 μg/kg) of selenocarrageenan syrupus increased mononuclear phagocyte englobement function, T lymphocyte proliferating function and delayed hypersensitivit significantly. All 3 doses increased serum haemolysin, IL-1, 2 activity and B lymphocyte proliferating function significantly. CONCLUSIION: The results suggest that selenocarrageenan syrupus could promote the immunological function of immune suppressed mice.

Key words: selenocarrageenan syrupus, nonspecific immunity, cell immunity, humoral immunity