Abstract: AIM: To study pharmacokinetic property of synthesized thymosin alpha 1(sTα1) after intravenous (i. v.) injection to monkeys. METHODS: Competition ELISA analysis was used for detecting drug concentration in serum after i. v. administration of sTα1 in monkeys. Pharmacokinetic parameters were calculated by DAS software. RESULTS: Pharmacokinetic model of sTα1 after i. v. was consistent with two-compartment open model, and in accordance with first-order kinetic elimination. CONCLUSION: Pharmacokinetic model after i. v. of sTα1 is two-compartment open model, and in accordance with first-order kinetic elimination.

Key words: thymosin, monkey, pharmacokinetics, enzymelinked immunosorbent assay