Study on the effect of anti-diabetes and cell protection of a new peptide S-8300

Abstract

Abstract: AIM: The purpose of this study was to evaluate the effect of anti-diabetes and cell protection of a new peptide S-8300 on streptozotocin diabetic mice. METHODS: The apoptosis induced by streptozotocin (STZ) in the diabetic mice was tested through cytometer and TUNEL technology. The biological activity was measured by MTT assay with mouse insulinoma β-cell line (NIT-1) which was exposed to the toxins STZ. RESULTS: S-8300 obviously reduced the rate of apoptosis in injured pancreas induced by STZ and it could also protect the structure integrity and recover the damage of NIT-1 cell after exposed to the toxin of STZ. CONCLUSION: The hypoglycemic mechanism of the anti-apoptotic effect of S-8300 may be related with the protective activity anainst the apoptosis.

Key words: S-8300, diabetes, apoptosis

CLC Number:

R965.2

HUANG Feng-jie, WU Wu-tong. Study on the effect of anti-diabetes and cell protection of a new peptide S-8300[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(11): 1283-1287.

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