Effects of the recombinant human growth hormone on recovery of nervous function with focal cerebral ischemia in rats

Abstract

Abstract: AIM: To investigate the effects of the recombinant human growth hormone (rhGH) on the recovery of nervous function with focal cerebral ischemia in rats. METHODS: The middle cerebral artery occlusion (MCAO) model was established by insertion of nylon thread in SD rats. The rhGH was given to the rats in the rhGH-treated group. The infarct size and recovery of nervous function were observed after MCAO. RESULTS: The infarct size in the rhGH-treated group (29±5) % was obviously smaller than that in the simple ischemia group (36±4) %.The recovery of nervous function in the rhGH-treated group was much better than that in the simple ischemia group. CONCLUSION: It is manifested that the rhGH can significantly reduce the injure of brain tissue and recover nervous function caused by cerebral infarction.

Key words: recombinant human growth hormone, cerebral ischemia, nervous function

CLC Number:

R965.2

LI Rong, LUO Chun-xia, CHI Lu-xiang. Effects of the recombinant human growth hormone on recovery of nervous function with focal cerebral ischemia in rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(11): 1288-1291.

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