Abstract: AIM: To observe multidrug resistance character of ESBLs and AmpC-producing isolated form Klebsiella pneumoniae in clinic, to analyze the existence and character of integron and to investigate the express of gene box involve drug resistance phenotypic.METHODS: MIC of the 4 strains was examined by micro-dilution method.Integron gene was determined by PCR assay with integron specific primer, and DNA sequencing was used for analyzing resistance related gene cassette.RESULTS: The 4 strains were multidrug resistance.The integron was detected in one strain of them, which carried aadA2 and dhfrXII gene.CONCLUSION: Though there is not the genes box of producing ESBLs and AmpC, integron involves in the form of multidrug resistance.

Key words: integron, gene box, multidrug resistance, Klebsiella pneumoniae beta-Lactamase, AmpC