Protective effects of CpG oligonucleotide on mice with bacterial sepsis and its mechanism

Abstract

Abstract: AIM: To investigate the protective effects and mechanisms of CpG ODN on mice with bacterial sepsis.METHODS: The mice with bacterial sepsis were injected with CpG ODN before infected by inactivated Escherichia coli to observe the protective role of CpG ODN. The serum TNF-αwas tested.RESULTS: Adequate dosage (2.5 mg°kg^-1) of CpG ODN protected mice from lethal challenge by inactivated Escherichia coli in a dose and time dependent manner.CpG ODN inhibited the release of TNF-αinduced by inactivated Escherichia coli. CONCLUSION: The potent anti-inflammatory effect of CpG ODN on mice with bacterial sepsis.The mechanism may be related to CpG ODN inhibiting the release of TNF- αinduced by inactivated Escherichia coli.

Key words: CpG ODN, bacterial sepsis, inactivated Escherichia coli, TNF-α, ELISA

CLC Number:

R966

LIU Wei, ZHOU Hong, DING Guo-fu, LU Yong-ling, WANG Liang-xi, LUO Ping. Protective effects of CpG oligonucleotide on mice with bacterial sepsis and its mechanism[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2005, 10(3): 314-317.

References

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