Abstract: AIM: To investigate the effects of seal oil ω-3 polyunsaturated fatty acids (ω-3 PUFA)on blood glucose research in insulin resistance diabetes rats. METHODS: Different dosage the seal oil ω-3 PUFA were administered to the insulin resistance diabetes rats model caused by the high fat feed chain streptozotocin. After administration for 6 weeks, the blood fats four items, blood sugar value, insulin value and liver glycogen were determined.RESULTS: The seal oil ω-3PUFA 4.8, 2.4, and 1.2 g°kg^-1 reduced the serum triglyceride levels by 44.1%, 43.5% and 6.5%, respectively, increased the serum HDL-cholesterol levels by 22.4%, 8.0% and 6.3%, respectively, and decreased the blood serum LDL-cholesterol levels by 27.9%, 23.6% and- 4.6%, respectively.The blood sugar value obviously decreased before the medicine by 31.6%, 13.3%,- 10.2%, respectively.But the insulin secretion was not decreased.The seal oil ω-3PUFA strengthened the sensitivity of organism to the insulin, and the sensitive index increased by 129.5%, 60.3%, 55.5%, respectively. CONCLUTION: The ω-3PUFA can effectively improve the insulin resistance syndrome caused by high glycerin trinitrate lipemia, and the mechanisms of it falls the sugar may be related to its enhancing the sensitivity of the organism to the insulin.

Key words: seal oilω-3PUFA, blood sugars, insulin, insulin resistance, insulin sensitivity