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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2004, Vol. 9 ›› Issue (7): 778-780.

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Effects of reteplase on fibrinolytic and coagulation systems in rabbits

DONG Liu-Yi, FAN Li, CHEN Zhi-Wu, JIANG Qin, FANG Ming, CEN De-Yi, CHEN Fei-Hu1, ZHI Qiang2   

  1. Department of Pharmacology, 1Department of Pharmacy, Anhui Medical University, Hefei 230032, Anhui, China;
    2Sangni Institute of Biotechnology, Heifei 230042, Anhui, China
  • Received:2004-04-05 Revised:2004-05-18 Online:2004-07-26 Published:2020-11-20

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Abstract: AIM: To investigate the effects of reteplase (Ret) on fibrinolytic and coagulation systems in rabbits.METHODS: The relative parameters of blood coagulation system and fibrinolytic systems were measured.RESULTS: Ret (3.75, 7.50, 15.0MIU·kg-1) lessened the content of plasminogen (Plg) and promoted the plasma fibrinogen degradation product (FDP) significantly, shortened plasma euglobulin lysis time (ELT), prolonged plasma thrombin time (TT), prothrombin time (PT), and active partial thromboplastin time (APTT).CONCLUSION: Ret can promote fibrinolytic system function and inhibit blood coagulation system function.

Key words: reteplase, tissue-type plasminogen activator, fibrinolytic system, coagulation system, rabbits

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