Abstract: AIM: To evaluate the efficacy and safety of a combination therapy of clarithromycin(CLA),colloidal bismuth subcitrate(CBS),and metronidazole(Met)in treatment of helicobacter pylori(HP)infection with recurrent abdominal in children.METHODS: By using the ¹⁴C-urea breath test(¹⁴ C-UBT)and serum HPIgG antibody test,28 patients of Hpinfection with recurrent abdominal pain were divided into treatment groupand control group.The treatment groupwas given CLA 15 mg·kg^-1 bid;CBS 8mg·kg^-1 bid;Met 18 mg·kg^-1 bid for1 wk.The control groupwas administered CLA 15 mg·kg^-1 bid;CBS 8 mg·kg^-1 bid;amoxicillin 40 mg·kg-1bid for 2 wk.All patients were followed-up4 wk after the treatment was completed and¹⁴C-UBT was repeated.RESULTS: Hperadication rates were 92.3% in treatment groupand 86.7% in control group(p>0.05).The pain relief rates were not statistically significant(p>0.05)between two groups.The side effects were 7.7%and 13.3% in treatment groupand control group,respectively.CONCLUSION: The combination of CLA +CBS+Met for 1 wk is an effective and safe treatment for eradication of Hpinfection with recurrent abdominal in children.

Key words: clarithromycin, colloidal bismuth subcitrate, metronidazole, helicobacter pylori, breath test